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It was originally FDA-approved for diagnosing and treating growth hormone deficiency in children, and its decades of clinical use have established a well-documented safety profile

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It is also well known that autocrine IGF-1 signaling affects mammary development

The mechanisms by which copper contributes to disease pathogenesis form an intricate network, centrally involving copper dyshomeostasis and its consequences, including oxidative stress (Rodriguez et al., 2024), protein aggregation (Zou et al., 2021), immune escape (Yi et al., 2022), angiogenesis (Tao et al., 2021)

Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)