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Clin Nutr (2021) 40:464452

Transforming growth factor-beta (TGF-) is a pleiotropic cytokine that regulates various cellular processes, including cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling [20]

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This stage of Lyme disease is so advanced that Lyme Literate Medical Doctors (LLMDs) often recommend intravenous antibiotics, administered through a peripherally inserted central catheter (PICC line)