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They can also show where findings depend on model design, assay conditions, and analytical methods

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These systems must not only transport therapeutic agents across the BBB, but also ensure targeted delivery to specific brain regions, minimize systemic toxicity, and optimize pharmacokinetics and pharmacodynamics [10]

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Likewise, knockout or knockdown of FATP5 in mice reduces hepatocyte fatty acid uptake, hepatic triglyceride content, and reverses steatosis [16, 17] indicating a role of FATP-mediated lipid uptake as a facilitator of hepatic steatosis

Autistic children with a co-occurring diagnosis of attention-deficit/hyperactivity disorder (ADHD, 32 ASD), anxiety disorders (1 ASD), oppositional defiant disorder (ODD, 4 ASD), dysthymia, or adjustment disorder (2 ASD) were not excluded