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Vardenafil could also enhance the delivery and therapeutic efficacy of herceptin monoclonal antibodies in mouse models of metastatic HER2/neu-positive brain tumors through stimulating caveolae-mediated endocytosis and micropinocytosis [92]

What remains critical is bridging the gap between bench and bedside: multi-center validation, simplification of workflows, and demonstrating that SCMO-based decisions improve patient outcomes