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The AES (Supplementary Note 1) were obtained using the BAC-knockouts as templates for a PCR using primers described in (Supplementary Table 2)

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Hyaluronic Acid Injections (Viscosupplementation) The goal of a hyaluronic acid injection is to temporarily lubricate and change the abnormal synovial environment of the knee joint, thereby decreasing knee pain and inflammation and improving knee function