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2 The main sources of cellular ROS are mitochondria and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and peroxisomes containing xanthine oxidase and the inducible form of nitric oxide synthase, which produce superoxide anion and nitric oxide, respectively

Examples of epithelial cell lines exploited in CF research are Fisher rat thyroid (FRT) (Sheppard et al., 1994) and CF bronchial epithelial (CFBE41o-) cell lines