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Instead, these strategies emphasize a multimodal approach that incorporates nonopioid medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and gabapentinoids as well as ketamine and lidocaine infusions

Negaro M, Skoulidis F, Montesion M, Schulze K, Bara I, Shen V, Hu S, Sui D, Elamin Y, Le X, Michael G, Murugesan K, Wu C, Zhang J, Barreto D, Robichaux J, Reuben A, Cascone T, Gay C, Mitchell K, Hong L, Rinsurongkawong W, Roarty E, Simon G, Roth J, Swisher S , Lee J, Tsao A, Papadimitrakopoulou V, Gibbons D, Glisson B, Singal G, Mille V, Alexander B, Frampton G, Albacker L, Shames D, Zhang J, Heymach J

[DOI] [PMC free article] [PubMed] [Google Scholar] 244.Mazumder M.A.R., Sukchot S., Phonphimai P., Ketnawa S., Chaijan M., Grossmann L., Rawdkuen S

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In AD, downregulation of E-cadherin disrupts intercellular cohesion, resulting in elevated TEWL and increased permeability to environmental allergens (Dong et al., 2024)