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Except for UDCA and LCA, primarily eliminated in feces, all conjugated and unconjugated bile acids in the lumen can be reabsorbed (95%) and returned to the liver (90)

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Moreover, expression of glutamate-cysteine ligase (GCL) and GSH synthetase was increased dramatically by QUR, in astrocytes and attenuated inflammation by repression of IL-1,6,8, monocyte chemoattractant protein-1 and ROS production release (Chen et al., 2006

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