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There were ruptured mitochondrial outer membrane, lessened mitochondrial cristae, increased mitochondrial membrane density, augmented green fluorescence emission, reduced , an elevated LC3II/I protein level, a lowered p62 protein level, abated cell viability, increased cell death, raised expression levels of inflammatory factors TNF-, IL-6 and IL-1, as well as ROS, Fe 2+ , MDA and LPO in the H/R + oe-SLC7A11 + RA group versus the H/R + oe-SLC7A11 + DMSO group (Fig