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As shown in Figure 1C, there was obvious severe cerebral cortex tissue loss in the TBI group relative to the sham group

Veldhuis JD et al

For antigen delivery, a modified vaccinia Ankara (MVA) virus and adjuvanted protein subunit approach in a heterologous prime-boost regimen were selected, as this has been proposed to elicit stronger, broader and/or longer-lasting immunity than homologous vaccinations 29