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Subsequent IFN- secretion by activated CD8 + T cells engages IFN receptors on glioma cells, triggering downregulation of cystine/glutamate antiporter subunits SLC3A2 and SLC7A11 ( Figure 7C )

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Importantly, FeS@SRB exerts excellent chemodynamic/photothermal synergistic effects compared to FeS@BSA in vivo, achieving efficient antitumor effects in multiple tumor models, including 4T1 subcutaneous tumor, B16F10 subcutaneous tumor and 4T1 orthotopic tumor (Figs