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Women taking long-term medications such as metformin (for diabetes or polycystic ovary syndrome) or proton pump inhibitors (for acid reflux) may also have reduced B12 absorption

On the other hand, their effects may vary according to plant variables such as chemotype, place of collection, climate, anatomical part from which the EO was extracted, altering significantly their composition and consequently their effects

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Both TFs act as master regulators of NE differentiation [42, 43]

In recent years, regular administration of probiotics, such as Bifidobacterium and Lactobacillus , has also been considered a potential method for preventing IBD (Manzoor et al., 2022), which further indicates the importance of the intestinal flora in IBD (Figure 2