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When activated by stress-induced hormonal imbalances, these pathways promote the production of pro-inflammatory cytokines and genes associated with oxidative stress, increasing the overall oxidative burden on cells (53)

48 Furthermore, different subsets of macrophages present distinct metabolic functions

however, a significant correlation was noted between vit-C levels and SARS-CoV-2 clearance rate among the obese patient group 723

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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)

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