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It has two forms: one is in an oxidized state and the other in a reduced state

The prokaryotic enzyme DsbB may share structural features with eukaryotic disulfide bond forming oxidoreductases

Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)