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This peptide is quick-acting, producing a rapid but relatively brief increase in GH levels

Icariin enhances macrophage phagocytosis, reduces spleen and thymus indices, downregulates pro-inflammatory cytokines (IL-6, IL-8, IL-1 ) in cervical cancer (SiHa) cells, and inhibits TGF- 1 protein expression in breast cancer (MDA-MB-231) cells, suggesting its immunomodulatory effects [708, 709]

doi: 10.1371/journal.pone.0042984 90 ClemenRArltKMiebachLvon WoedtkeTBekeschusS

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To be emphasized, differential metabolites were also found between DM-ILD and DM-nonILD in this study, mainly including glycerolipid, sphingomyelin, and LPE