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Inhibitory actions of opiates and synthetic opioids on secretomotor neurons and cholinergic neurotransmission in the ENS account for much of their constipating action

Carcinoma 8 , 899912 (2021)

This review highlights established and emerging concepts, unanswered questions, and future challenges for development and optimization of GLP-1R agonists in the treatment of metabolic disease.

Glutaminase inhibitor CB-839 is now under clinical trials to evaluate safety and efficacy in combination with other anticancer drugs in cancers (Table 1)