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However, results have been poor because neurotrophins do not readily cross the blood-brain barrier and degrade rapidly in biological medium [14]

10.1016/j.pharmthera.2017.02.005 39 ElettoD.DershD.ArgonY

These complexes facilitate electron transfer and ATP synthesis

In the previously cited clinical study,9 the elderly subjects received 100 mg/kg of both NAC and glycine for 14 days, and their red blood cell total glutathione levels (reduced glutathione plus diglutathione) rose from 1.26 mmol/L at baseline to 2.23 mmol/L, a concentration slightly higher than that measured in young subjects who did not take supplements.9 Moreover, the ratio of reduced glutathione to diglutathione rose from 7.4:1 to 16.1:1, indicative of a substantial improvement in redox status as confirmed by concurrent reductions in plasma markers of oxidative stress

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