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doi: 10.3389/fcell.2025.1611055 Received 13 April 2025 Accepted 02 June 2025 Published 16 July 2025 Volume 13 - 2025 Edited by Rosa Vona, National Institute of Health (ISS), Italy Reviewed by Sidra Islam, Case Western Reserve University, United States Sajal Sen, Massachusetts Institute of Technology, United States Updates Copyright 2025 Qi, Mu, Hu, Li and Liu

ABBREVIATIONS 6-MP 6-mercaptopurine 6-TG 6-thioguanine (6-mercaptopurine and 6-thioguanine) CAO 4-[N-(S-cysteinylacetyl)amino]phenylarsonous acid cAVTP cis-6-(2-acetylvinylthio)-purine CPIC p-chlorophenyl isocyanate DMAC dimethylarsino-cysteine DMACG dimethylarsino-cysteinylglycine EGFR epidermal growth factor receptor GSH glutathione GCAO 4-[N-(S-cysteinylglycylacetyl) amino] phenylarsonous acid GT gamma-glutamyl transferase GSAO [4-(N-(S-glutathionylacetyl) amino)phenylarsonous acid] GS-cAVTP glutathione s-cis-6-(2-acetylvinylthio)-purine Glu glutamate Gly glycine GS-tAVTG glutathione s-trans-6-(2-acetylvinylthio)-guanine PENAO 4-(N-(S-penicillaminylacetyl)-amino)phenylarsonous acid SCPG S-(N-pchlorophenylcarbamoyl) glutathione tAVTG trans-6-(2-acetylvinylthio)-guanine

doi: 10.1186/1550-2783-2-2-38

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The size of the peripheral vein limits the amount and rate of medication which can be administered safely