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It also discusses how these insights may inform targeted treatment strategies (92)

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Supplementary material The Supplementary Material for this article can be found online at: Glossary 4EBP1 Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 ADNVs Aloe-derived PDEVs AF4 Asymmetric Flow Field-Flow Fractionation AFM Atomic Force Microscopy ALP Alkaline Phosphatase AM Acrylamide ASC-Exos Antler Stem Cell-derived PDEVs ATP Adenosine Triphosphate ATPS Aqueous Two-Phase System BGP/OCN Bone Gla Protein/Osteocalcin BMP Bone Morphogenetic Protein BMSCs Bone Marrow-derived Mesenchymal Stem Cells cAW centrifugation-based washing Cabex Cabbage-derived PDEVs C-CP Capillary channel polymer C-dots Carbon dots CDEs Carrot-derived PDEVs CDENs Coriander-derived PDEVs CELNs Celery-derived PDEVs C-EVs Cactus Extracellular Vesicles CLEVs Lemon-derived PDEVs CM Chondrocyte Membrane COL2/ACAN Collagen Type II/Aggrecan COMP Cartilage Oligomeric Matrix Protein COX-2 Cyclooxygenase-2 CQ-ELNs Cissus Quadrangularis PDEVs DGC Density Gradient Centrifugation DLS Dynamic Light Scattering DMSO DiMethyl SulfOxide DOX Doxorubicin Drp-1 Dynamin-related protein 1 ECM Extracellular Matrix ELISA Enzyme-Linked Immunosorbent Assay ENs wintergreen-derived PDEVs EpCAM Epithelial Cell Adhesion Molecule ER Endoplasmic Reticulum ERK Extracellular signal-Regulated Kinase EVs Extracellular Vesicles EXPO EXocyst-Positive Organelle FFF Field Flow Fractionation GelMA Gelatin Methacryloyl GENs Ginseng PDEVs GIT GastroIntestinal Tract GNVs Grapefruit-derived Nanovesicles GqDNVs Goji berry-derived PDEVs hUCMSCs Human Umbilical Cord Mesenchymal Stem Cells HBsAg Hepatitis B Surface Antigen HIF-1 Hypoxia-Inducible Factor-1alpha HO-1 Heme Oxygenase-1 HPCA Hippocampal CD11b HPLC High-Performance Liquid Chromatography HUVECs Human Umbilical Vein Endothelial Cells IB Inhibitor of Nuclear Factor Kappa B Alpha IGF-1 Insulin-like Growth Factor-1 IL-6 Interleukin-6 ILVs Intraluminal Vesicles ISEV International Society for Extracellular Vesicles JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated protein 1 lEVs Large Extracellular Vesicles miRNA microRNA mTOR mammalian Target Of Rapamycin MAPK Mitogen-Activated Protein Kinase Mef2D Myocyte Enhancer Factor 2D MoEVLPs Morinda Officinalis-derived PDEVs MEK1/2 MAPK/ERK kinase 1/2 MMPs Matrix Metalloproteinases MS Mass Spectrometry MSCs Mesenchymal Stem Cells MVB Multivesicular Body MWCO Molecular Weight Cut-Off Nrf2 Nuclear factor erythroid 2-related factor 2 NADPH Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor Kappa-Light-Chain-Enhancer of activated B cells NFATc1 Nuclear Factor of Activated T-cells, Cytoplasmic 1 NLRP3 NOD-, LRR- and pyrin domain-containing protein 3 NOX4 NADPH Oxidase 4 NTA Nanoparticle Tracking Analysis NTU NanoTized Unit (from spinach) OA OsteoArthritis OATNs Oat-derived PDEVs OPN Osteopontin ORI Oregonin I p70S6K Ribosomal protein S6 kinase beta-1 piRNA Piwi-interacting RNA PBS Phosphate-Buffered Saline PDEVs Plant-derived Extracellular Vesicles PDNVs Plant-derived Nanovesicles PEG Polyethylene Glycol PgEVs Pomegranate-derived PDEVs PI3K/Akt Phosphoinositide 3-kinase/Protein Kinase B PPAR- Peroxisome Proliferator-Activated Receptor Gamma PVA PolyVinyl Alcohol Rabex Red cabbage-derived PDEVs RANKL Receptor Activator of Nuclear Factor Kappa-B Ligand Runx2 Runt-related transcription factor 2 ROS Reactive Oxygen Species sEVs Small Extracellular Vesicles sRNA small RNA S100A4 S100 Calcium Binding Protein A4 SEC Size Exclusion Chromatography SDS-PAGE SDS-polyacrylamide gel electrophoresis SOX9 SRY-box transcription factor 9 SP-EVs Spirulina-derived PDEVs STS Staurosporine Syk Spleen tyrosine kinase TA Tannic Acid TELVs Tomato-derived PDEVs TEM Transmission Electron Microscopy TGN trans-Golgi network TLC Thin-Layer Chromatography TNF- Tumor Necrosis Factor-alpha UC Ultracentrifugation UF UltraFiltration UV-MALS Ultraviolet-Multi-Angle Light Scattering vAW vacuum-assisted washing VIB Vesicle Isolation Buffer VSMC Vascular Smooth Muscle Cell YAP1 Yes-associated protein 1 References 1 AbelsE

Experimental models show that this dual activation can influence both the magnitude and temporal pattern of growth hormone signaling, providing a framework for studying receptor synergy and signal integration [6]

Theoretical study of the antioxidant activity of vitamin E: reactions of -Tocopherol with the hydroperoxy radical

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