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It also helps regulate homocysteine levels, which is important for cardiovascular health

The cardiovascular and respiratory side effects include chest pain, tachycardia (increased heart rate), heart palpitations, low blood pressure, and chest tightness, cough with or without production of pink frothy sputum, wheezing and difficulty breathing

Patients were given a single tablet of B vitamins containing 2.5 milligrams of folic acid, 25 milligrams of vitamin B6 and one milligram of vitamin B12 per day for 36 months or a matching placebo

More frequent checks may be warranted if adjusting doses or experiencing symptoms

Here is the standard titration schedule used in clinical research: Each phase lasts four weeks