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In the meantime, cisplatin resistance was reversed by berberine and cisplatin combination therapy, which suppresses the PI3K/Akt signaling and increases caspase-3 and caspase-9 activation to cause apoptosis (116)

[3] Anti-Inflammatory and Gene-Regulatory Actions A 2012 bioinformatics analysis by Pickart et al., using the Broad Institute Connectivity Map, found GHK-Cu modulates expression of more than 4,000 human genes, with pathways spanning inflammation suppression, DNA repair, and antioxidant defense

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Re-addition of cystine restored of mTORC1 signaling, which was abolished by rapamycin (Fig