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When found in aqueous solutions, mannitol tends to become acidic

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Biological and technical replicates: clearly distinguish in planning and reporting biological replicates (independent animals) from technical replicates (repeated measurements on the same sample)

First, the molecular trigger specificity of oxalate-induced ferroptosis in renal tubular cells is undefinedhow oxalate precisely initiates the synergistic dysregulation of iron uptake (TFR1), lipid metabolism (ACSL4), and antioxidant defense (GPX4/SLC7A11) remains elusive, with no clarity on upstream signaling molecules or post-translational modifications that link oxalate exposure to ferroptosis machinery

Therefore, strategies to increase ROS levels for cancer cell death, especially in advanced stages, are promising (Fig