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Diabetics and others with impaired glucose tolerance are highly susceptible to the tissue-damaging effects of advanced protein glycation, a process that occurs when blood sugar reacts with body proteins resulting in various accumulated destructive effects on blood vessels, nerves, and the lens of the eye

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doi: 10.1111/j.1365-3083.2009.02253.x 118 PangburnMKMller-EberhardHJ

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Both molecules decrease as you age through different mechanisms and at different rates, with NAD+ dropping by approximately 50% and glutathione synthesis slowing by 45% between ages 20 and 60