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SOD1 WT misfolding has been shown to occur in the spinal cord of sporadic (sALS) and non-SOD1 fALS patients 13,14,18,19,20,21,22,23 , and it was proposed that misfolded SOD1 WT and mutant proteins (SOD1 MUT ) share a common pathogenic pathway in ALS 18,23,24

Gene therapy and emerging approaches Emerging gene therapy approaches further expand the therapeutic landscape

DNA damage, defective DNA repair, and neurodegeneration in amyotrophic lateral sclerosis

10.1007/978-1-4613-0537-8_22 189 SteenV

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Plant Physiol 163:665671 Ogawa KI (2005) Glutathione-associated regulation of plant growth and stress responses