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It's important to note that the body can only metabolize a certain amount of alcohol per hour, and consuming alcohol faster than the body can process it leads to higher BAC levels, which can have legal and health implications

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* Correspondence: Ranmali Ranasinghe, [email protected] ORCID: Ranmali Ranasinghe, orcid.org/0000-0003-3634-2689 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Hepatocyte-specific mitochondrial ribosomal protein CR6-interacting factor 1 (CRIF1) deficiency increases PD-1 expression and creates an adverse environment for T cells, which results in T cell fatigue due to elevated reactive oxygen species and lactate generation [137]

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