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Metabolomic analyses have revealed higher concentrations of amino acids, especially glutamine, in CRC cells containing mutated KRAS than in wild-type CRC cells (162)

It consists largely of three amino acids: glutamine, glycine, and cysteine

examined the stability of different formulations of LNPs loaded with mRNA (mRNA-LNPs) before and after nebulization using a VMN [141]

10.1039/c7mt00156h 287 Ozyerli-GoknarE.Bagci-OnderT

Glutathione Glutathione is often dubbed the master antioxidant due to its pivotal role in maintaining cellular health and combating oxidative stress, one of the key factors contributing to aging and many chronic diseases

This approach not only produces synergistic effects across these levels but also enhances drug delivery efficiency and mucosal retention through the use of natural polymeric materials, thereby comprehensively improving the efficacy of 5-ASA ( FIGURE 2 2.2 Combination of TCM formulations and 5-ASA: holistic multi-target regulation The combination of TCM formulations with 5-ASA demonstrates multidimensional synergistic advantages in clinical efficacy, mechanisms of action, and safety, significantly expanding the scope of disease management beyond conventional 5-ASA monotherapy