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Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide [0.03-, 0.07-, and 0.5-fold the maximum recommended human dose (MRHD) of 15 mg once weekly based on AUC] during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

Specifically, LPS-introduced PE placentas were used to compare with NT group to identify pathogenic differences

Auerbach BD, Rodrigues PV, Salvi RJ

Lipo B12 or MIC injections combine B12 with lipotropic agents that promote fat metabolism, detoxification, and liver support

doi: 10.1016/j.bbamem.2020.183400 144 VosM.Dulovic-MahlowM.MandikF.FreseL.KananaY.Haissatou DiawS.et al