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10.3390/ijms23020996 145 YangX

[21] Systemic absorption of topical tretinoin is low, yet sporadic case reports have raised theoretical teratogenic concerns

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Another study by Rambo et al., evaluated the effects of acute creatine administration (300 mg/kg orally) on intraperitoneal PTZ-induced electrographic, oxidative, and neurochemical alterations, and mitochondrial membrane potential in rat cerebral cortex (Rambo et al., 2013)

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Decreased SOD activity is correlated with heightened levels of oxidative damage, encompassing membrane lipid peroxidation, protein carbonylation, and DNA fragmentation [32]