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IL-1 is a crucial downstream effector of NLRP3 following vaccination and its production is predictive of vaccine side effect intensity [39]

Although the role of bombesins in modulating mucus secretion or muc5AC/muc5B regulation in COPD is unknown, given that bombesins are increased in COPD [193] and muc5B is also increased [188], then it is possible that either a direct or indirect relationship between bombesin signaling and muc5B expression exists

High levels of lipid peroxidation-derived aldehydes, including 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) [92], protein glycoxidation markers such as pentosidine [93], and stress-induced DNA damage molecules, more specifically 8-hydroxy-2-deoxyguanosine (8-OHdG) [94, 95], have also been revealed in the spinal cord from sALS patients

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