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Interestingly, inhibition of CIA was observed even when ICOSL blocking antibody was given after the onset of disease (114)

Tor/mTOR is a serine/threonine kinase with a molecular weight of approximately 289 kDa and is classified within the phosphoinositide 3-kinase-related kinase (PIKK) family owing to structural similarities in its catalytic domain

doi: 10.3390/cells11182857 48 ChavisPShinozakiHBockaertJFagniL

It is important to emphasize how this kind of degeneration differs from OHC apoptosis, which features cell shrinkage, membrane blebbing, karyorrhexis, and apoptotic bodies