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doi: 10.1016/j.jep.2024.117965 101 ZhangNYeTLuXLiZLiL

The World Health Organization (WHO) (International Agency for Research on Cancer) predicts a rise in global cancer incidences to 30.2 million globally by the end of 2040, with a 96% rise in cancer incidences in countries having a low HDI (GLOBOCAN 2020 report, 2020)

Nilotinib is a tyrosine kinase c-Abl inhibitor approved for the treatment of leukemia, that has also shown to increase autophagy and degradation of intracellular -syn aggregates (Fig

Dual Agonists: The Twincretins The next major step in development involves drugs that combine a GLP-1 agonist with another hormone, a GIP (glucose-dependent insulinotropic polypeptide) agonist