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From the historical perspective, symbolic AI, as the mainstream approach from 1950 to the early 1980s, did not scale up to complex real-world scenarios, for example, to model the natural language that people use in their daily life 17,18

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This cascade of oxidative damage and barrier dysfunction is increasingly recognized as a core mechanism linking neuroinflammation to the neurodevelopmental abnormalities observed in ASD (El-Ansary et al., 2018