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Human gut has little capacity to synthesize Glutamine and therefore it relies on the glutamine supply by other tissues and diet

John's wort, a supplement Tryptophan, a supplement Antidepressant medications are a concern because of a complication called serotonin syndrome

I suppose you could say that a lack of side effects implies a lack of results

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A disadvantage is that many trials are 'placebo-controlled', which means that there is a chance that the participant does not receive the medicine but a placebo