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142 ViolanteS.IJlstL.Te BrinkeH.KosterJ.De AlmeidaI

Therefore, controlled antioxidant supplementation may be useful to preserve sperm quality along the life-span [132,133]

Glucocorticoids represent the mainstay of management of irAEs, but other immunosuppressive drugs can be used to mitigate refractory irAEs

IM-25 ( 57 ) is a novel amino benzoic acid DNMTi screened from 169 procainamide derivants by the Ohio State University, which caused the reversal of promoter hyper methylation of GSTP1 and TRIP10 genes in MCF7 breast cancer cells and induced global hypomethylation and hypomethylated more loci than procainamide and 5-aza-2-deoxycytidine (Lin et al., 2011b)