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In POF, the ovaries lose their germinative and hormonal functions because of the exhaustion of the number of ovarian follicles before the typical age for physiological menopause which is around 50 years of age

Ferroptosis describes a form of regulated cell death that is driven by unrestricted lipid peroxidation, which does not require the activation of caspase and can be suppressed by iron chelators, lipophilic antioxidants, inhibitors of lipid peroxidation, and depletion of polyunsaturated fatty acids

Low NAD+ leads to unstable genes and poor DNA damage response

DOI: 10.1016/j.cryobiol.2016.02.008

Recommended storage guidelines include: Store in a cool, dry location

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