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Conclusion Despite significant progress in the management of cardiac iron overload in -thalassemia patients, cardiovascular disease remains the leading cause of death in this population

This is because the gut and liver are anatomically linked via the portal system (14)

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

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However, imbalanced redox causes oxidative damage to important intracellular biomolecules, leading to abnormalities in the structure and function of cells [9]

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