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Nat Neurosci 8:11391141

SAG uses a thioester (S-acyl) bond, which is cleaved specifically by cytoplasmic thioesterases, offering a more targeted intracellular release mechanism with a cleaner safety profile demonstrated in human dosing studies

10.3389/fphar.2020.00239 60 HirschhornT.StockwellB

10.1016/j.cmet.2020.03.006 Cell Metab

The main impurity in NAC is Di-NAC which is formed in all the stress conditions due to the high susceptibility of the thiol moiety to oxidize and form disulphide ( Figure 1 )