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10.1161/JAHA.117.006347 48

Therefore, the specific physiopathology of the aging heart should be considered before applying NAD+ supplementations

All patients were treated with a local application of 0.03% tacrolimus twice daily for 3 weeks and then 0.1% tacrolimus for the next 3 weeks

We then conducted Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and Gene Ontology (GO) analyses to explore the biological functions of the upregulated and downregulated DEGs (Fig

However, clinical evidence remains limited, and future studies are needed to verify whether combined nutritional or pharmacological interventions can provide protective effects during exercise in patients with mitochondrial myopathy