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Interestingly, this combination has also seen to have a positive effect on sperm quality and sperm motility

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

Upon activation by environmental signals, they bind to cis-acting elements (e.g., MYBCORE, AC-box, P-box, H-box, G-box) in target gene promoters, either independently or in complexes with other proteins, to modulate stress-responsive gene expression (Zhang et al., 2025)