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As an outlook, the simultaneous inhibition of essential oxidative stress response enzymes by the 5-nitroimidazole ether analogues causes a perfect storm of damage and attenuated rescue (Fig

More importantly, we discovered the novel mechanism that LPS stimulation triggered a classic protein kinase C (cPKC)-dependent phosphorylation of GSTP and translocation of GSTP from cytoplasm to nucleus

Deep learning will expand the capability of analyzing these complex data sets 116

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For example, early postnatal alcohol exposure leads to persistent hypermethylation of the FKBP5 promoter in the hippocampus, likely disrupting HPA axis feedback regulation and enhancing susceptibility to depression-like phenotypes through epigenetically mediated stress-response dysregulation 172