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102,103 Exercise-induced IGF1 activates IGF1 receptor (IGF1R) tyrosine kinase, which can recruit the SH2 domain-containing protein such as the p85 regulatory subunit of Class IA PI3K

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doi: 10.1101/cshperspect.a028431 123 FluhrerRGrammerGIsraelLCondronMMHaffnerCFriedmannEet al

pharmaceutics 478 , 517529 (2015)

These patients were evaluated with photo documentation at 4 weeks, 6 weeks and 12 weeks

The mechanism is related to metabolic regulation and increased chemosensitivity of cancer cells: by inhibiting NNMT, the product disrupts the energy supply of cancer cells, making them more vulnerable to chemotherapy, while protecting the metabolic balance of normal cells and reducing side effects