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Choline is an essential nutrient that has a number of vital biological functions (see the article on Choline)

"The homocysteine hypothesis of depression"

Serine-driven mitochondrial metabolism contributes to 5-FU resistance by supporting purine nucleotide biosynthesis, thereby facilitating the repair of chemotherapy-induced DNA damage 154

This condition is characterized by numbness or tingling in the hand caused by a pinched nerve ( Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes ( Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes ( Reduces inflammation Chronic inflammation is linked to several diseases, including cancer and diabetes

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Neuroinflammation in ME/CFS was initially suggested by studies showing elevated levels of pro-inflammatory cytokines, and decreased anti-inflammatory cytokines, in cerebrospinal fluid from lumbar punctures in ME/CFS patients [62, 63], and further supported by a positron emission tomography (PET) study [64], which showed increased binding of a radioligand to 18 kDa translocator protein (TSPO) receptor, the expression of which increases when microglia are activated