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doi: 10.1507/endocrj.EJ18-0487 65 MaoZGHeDSZhouJYaoBXiaoWWChenCHet al

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This can lead to acute kidney injury, fluid retention, elevated potassium levels, and high blood pressure

As well as being activated by other oncogenic signalling pathways, such as in those tumours driven by loss of Phosphatase and tensin homolog (PTEN) or aberrant WNT signalling, 32,33 macropinocytosis can also be induced by the metabolic microenvironment of the tumour, as shown by macropinocytosis of albumin-associated free fatty acids by colorectal cancer cells through G protein-coupled receptor 120 (GPR120)

Thus, the thyroid gland is under increased TSH stimulation, fails to respond to exogenous TSH, and has a rapid turnover of thyroidal iodine

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