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The resulting trifluoromethyl derivative 5 showed a potent antimalarial activity per se against malarial parasites in culture

doi:10.2183/pjab/84.246 Fleshler B, Butt JH, Wismar JD

A phase I clinical trial sponsored by Imago BioSciences to evaluate the safety, steady-state pharmacokinetics, and pharmacodynamics of IMG-7289 alone or in combination with ATRA in the treatment of AML and MDS patients has been completed (ClinicalTrials.gov Identifier: NCT02842827)