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It is recommended that metformin treatment should continue while the B12 deficiency is corrected, in view of the drugs known benefits in type 2 diabetes and its central role in treatment guidelines.

Lean, metabolically healthy profiles use roughly 0.3 to 0.5 mg because exposure and heart-rate sensitivity are higher at the same nominal dose. These sub-1 mg ranges are modeled rather than outcome-tested

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The actin-binding region itself has been linked to vascular activity: a 2003 study in the FASEB Journal reported that the site promoting actin interaction is also associated with angiogenic activity in experimental models