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Misoprostol, an FDA-approved prostaglandin analog, prevents NSAID-induced ulcers with a number needed to treat (NNT) of approximately 8 based on the MUCOSA trial 12

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In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

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