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High-antioxidant foods were also encouraged since antioxidants are important for reducing the oxidative stress triggered by glutamatergic excitotoxicity (100, 101)

Clinical trials show minimal side effects, even at higher doses

The most common lethal factors triggering ferroptosis are intracellular iron overload and excessive lipid peroxidation [23, 24]

Bibcode:2007PNAS..104.8374T

Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]

Many mechanisms of arsenic-induced carcinogenicity have been proposed like DNA repair inhibition, oxidative stress, epigenetic events, effect on signal transduction and genotoxic damage