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Some bacteria are naturally resistant to certain antibiotics, but others can acquire resistance through mutations or horizontal gene transfers via transformation, transduction or conjugation [32, 33]

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This does not diminish the importance of kynurenine limitation, instead, it highlights the need for precise patient stratification, optimized combination strategies, targeting additional pathway nodes, or directly inhibiting AhR with antagonists

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Clinical indicators of VAD include night blindness, xerophthalmia fundus, conjunctival and corneal xerosis, Bitot spots, corneal ulcers, and scarring

NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis