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Total protein was extracted with a combination of RIPA buffer (Sigma Aldrich, US) and a protease inhibitor cocktail (Roche, Shanghai, CN) per the manufacturers instructions

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Phylogenetic analysis revealed that the majority of these hits belong to the family of Treponemataceae which constitute a large clade that are rooted from the CFB (Cytophaga, Fusobacterium, and Bacteroides) group bacteria from human oral and gut microbiota (Appendix Fig

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Autism spectrum disorder (ASD) is an extremely heterogeneous condition characterized by delays in reciprocal social interaction and communication skills, stereotyped behaviors, and a narrowed range of interests and limited activities