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The PI at this center holds the ultimate responsibility for the entire trial

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While semaglutide pharmacokinetics are not significantly altered in patients with hepatic impairment, the medication has not been extensively studied in patients with severe hepatic dysfunction

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However, over-emphasis on any one nutrient or monotonous food is not recommended (Katz and Meller, 2014), since the lack of variety in dietary products can cause malnutrition and imbalance in consumed nutrients

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[PubMed] 17.Beiderbeck D., Frevel N., von der Gracht H.A., Schmidt S.L., Schweitzer V.M

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GLP-1 peptides (semaglutide, tirzepatide, retatrutide) Semaglutide , tirzepatide , and retatrutide are highly potent GLP-1 compounds

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Side effects typically peak around weeks 6-8, then improve significantly by week 12

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